Studies on the mechanism of toxicity of the chlorinated dibenzo-p-dioxins.

نویسندگان

  • A Poland
  • E Glover
چکیده

Concern about the potential health hazards resulting from environmental pollution by the chlorinated dibenzo-p-dioxins and dibenzofurans arises from our recognition of the extraordinary potency of these compounds as toxins and teratogens and their inadvertant dispersion in the environment as contaminants of chlorinated phenolic products. Questions concerning the extent of environment contamination and those concerning the mechanism of toxicity produced by these compounds are at present unanswerable. Several papers in this symposium have presented the historical background which led to our current understanding and concern about this problem: (1) the "chick-edema" outbreaks caused by "toxic fats" in poultry feed and the eventual isolation and identification of a hexachlorinated dibenzo-p-dioxin; (2) the occurrence of acne among workers in several 2,4,5-T factories and recognition of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as the etiologic agent; (3) the NCIcommissioned study on the potential teratogenicity, carcinogenicity and mutagenicity of 2,4,5-T; (4) and the widespread use of Agent

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عنوان ژورنال:
  • Environmental Health Perspectives

دوره 5  شماره 

صفحات  -

تاریخ انتشار 1973